PittPharmacy_WenXie_270Wen Xie, MD, PhD was awarded a new R01 grant for The Hepatic Function of Cholesterol Sulfotrasferase 2B1b (SULT2B1b)in Energy Metabolism.

The cholesterol sulfotransferase SULT2B1b is a cytosolic sulfotransferase best known for its activity in sulfonating cholesterol and oxysterols. The goal of this study is to determine the role of SULT2B1b and its enzymatic byproduct cholesterol sulfate in energy metabolism and metabolic syndrome. Xie and his group hypothesize that the cholesterol sulfotransferase SULT2B1b has a previously unrecognized role in controlling energy metabolism and the pathogenesis of metabolic disease.

Results from this study may establish SULT2B1b as a novel therapeutic target to treat and prevent obesity and type 2 diabetes.

Wen Xie is The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, Professor of Pharmaceutical Sciences and Pharmacology, in the Pharmaceutical Sciences Department at the School of Pharmacy.

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